Experimental testing represents the basic approach for mechanical characterization. Due to the high costs for test execution, the research is often developed with the collaboration of several laboratories, finally collating al the results. At this stage problems may arise due to data scattering, often due to (lateral or angular) misalignments between the fixed and the moving machine crossheads. The object of this work is to manufacture and experimentally validate a novel loading-constraining device for misalignment compensation. Conceptual design is applied to investigate on the optimal technical solution. The developed device achieves misalignment reduction with the use of a thrust bearing with sphered housing washers. The bearing is mounted under one of the specimen heads: the inverted orientation of the upper ring, allowing relative lateral displacement between the two rings, and the spherical shape of the washer compensate for offset and angular misalignments. Experimental results showed that such misalignments are respectively reduced to less than 0.02 mm and 0.05°, while the bending strain is lowered to just 6% of the nominal one, so that requirements in different standards for mechanical testing can be fulfilled.