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In last decades are wide spread the attempts to make use of from fracture mechanics (FM)parameters and criteria in evaluation life assessment and operation reliability of materialsand structures. In spite of such approaches the paper considers several categories of thelife assessment problems which cannot be resolved on the base of the FM-methodology.Among them evaluation of fatigue longevity of high strength materials, long term loading ofalloys in corrosive environments, evaluation of some structural embrittlement of metals.The necessity to create the new stress, strain and energetic criteria and parameters of crackinitiation, which are not derivative from the FM parameters, is underlined.