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In this paper a sensitivity analysis is performed on a finite element model previously developed to study the fatigue behaviour of cemented hip prostheses. The proposed method is based on a “smeared-crack” technique to simulate the evaluation of the fatigue damage process in the cement mantle. The non-linear and anisotropic behaviour of the material after it is locally cracked is simulated by the finite element code ABAQUS®. In this paper the sensitivity of the stem subsidence and damage level in the mantle is studied as function of the cement Young modulus, the stem-cement friction coefficient and the stem Young modulus. Numerical results show a significant sensitivity to variations of the cement Young modulus and stem-cement friction coefficient and a moderate sensitivity to the stem Young modulus.