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The paper presents new experimental multiaxial fatigue data on cast iron. Several sets of specimens, taken from a real large component, have been tested under uniaxial and biaxial, tensile and torsional loading; in-phase and out-of-phase combined loading have been considered too. Obtained results have been even compared with similar experimental data taken from literature and the tested material showed a high sensibility to mean value of shear stress under torsional loading, as well as the dependence from the mean value of tensile stress under tensile loading. The more suitable fatigue criterion should be related to the larger principal stress variation, but the materials shows even an unusual sensibility to out-phase loading.