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A multiaxial model for fatigue life estimation based on a measure of combined deviatoric strain amplitudes, together with the amplitude and the mean value of the hydrostatic stress, is presented in this work. Assessment considered 166 proportional and non-proportional strain-controlled programs reported in the literature, including a number of cases with mean strains/stresses, for two’ steels and two aluminum alloys. The resulting life estimates correlated well with the experiments, falling in most cases within a bandwith of factor two.