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Improved understanding of the interactions of fatigue, creep and environmental damage mechanisms has enabled design engineers to extend the operating temperatures of existing alloys. The current paper investigates these effects in the titanium alloy Ti6246 in terms of the growth of fatigue cracks from notched specimen geometries and plain samples. Partitioning of these damage mechanisms is shown to be possible, and the development of a modelling capacity which encompasses both fatigue crack intiation and growth is subsequently reported.